FKB1A Polyclonal Antibody, 100ul Immunology This gene encodes a member

This gene encodes a member of the tyrosine kinase and| more specifically| the Janus kinases (JAKs) protein families

Alternative splicing of KRT13 results in multiple transcript variants

A mutation in this gene was found in a family with Stickler syndrome

The encoded protein is involved in several cellular processes| including autophagic vesicle formation| mitochondrial quality control after oxidative damage| negative regulation of the innate antiviral immune response| lymphocyte development and proliferation| MHC II antigen presentation| adipocyte differentiation| and apoptosis

subcellular location:Distributed throughout the cytoplasm and also localizes to the perinuclear region of both human erythroleukemia (HEL) cells and Jurkat cells

FKB1A Polyclonal Antibody, 100ul Immunology This gene encodes a memberThe protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF beta receptor. It also interacts with multiple intracellular calcium