MDM2 Polyclonal Antibody, 100ul[BT-AP05300] Multiplex Immunoassays an apoptosis-promoting nuclear RNA-binding protein

an apoptosis-promoting nuclear RNA-binding protein

Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore

Related pseudogenes are located on chromosomes 1 and 9

that is required for anchoring microtubules to subcellular structures

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MDM2 Polyclonal Antibody, 100ul[BT-AP05300] Multiplex Immunoassays an apoptosis-promoting nuclear RNA-binding proteinMDM2 encodes a nuclear localized E3 ubiquitin ligase. E3 ubiquitin protein ligase Mdm2 can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. MDM2 is itself transcriptionally regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript