FXR2 Polyclonal Antibody, 100ul Mammalian Expression binds both the retinoblastoma protein

binds both the retinoblastoma protein (Rb)

but causes G2-M arrest in p53-null or –mutant cells

This gene is also suspected of having an oncogenic role in medulloblastoma

Expression of this gene is increased after vascular endothelial growth factor (VEGF) stimulation in human leukemia cell lines and results in inhibition of apoptotic cell death induced by irradiation or exposure to etoposide

10) and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias

FXR2 Polyclonal Antibody, 100ul Mammalian Expression binds both the retinoblastoma proteinThe protein encoded by FXR2 (FMR1 autosomal homolog 2) is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental retardation syndrome.