OTOAN Rabbit Polyclonal Antibody, 100ul Glassware Alternative promoter usage results in

Alternative promoter usage results in two different transcript variants which encode the same protein

Alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus

and splenic follicular dendritic cells

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Sequence analysis identified three transcript variants that encode two different isoforms

OTOAN Rabbit Polyclonal Antibody, 100ul Glassware Alternative promoter usage results inThe protein encoded by this gene is specifically expressed in the inner ear and is located at the interface between the apical surface of the inner ear sensory epithelia and their overlying acellular gels. It is prposed that this protein is involved in the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells. Mutations in this gene are associated with autosomal recessive deafness type 22 (DFNB22).