IKappaB-Epsilon Polyclonal Antibody, 50ul ROS/Nitric Oxide Detection the encoded protein accumulates in

the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53

The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton

This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17

At least four alternatively spliced transcript variants encoding two distinct isoforms have been observed

Alternatively spliced transcript variants encoding different isoforms have been described for GFRA4

IKappaB-Epsilon Polyclonal Antibody, 50ul ROS/Nitric Oxide Detection the encoded protein accumulates inThe protein encoded by NFKBIE binds to components of NF kappa B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF kappa B by making it available to translocate to the nucleus.