Shc(Phospho Tyr427) Polyclonal Antibody, 50ul Cell Culture Flasks subcellular location:Localized at the plasma

subcellular location:Localized at the plasma membrane in areas of cell-cell contacts and at the cell surface of PMN

May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A

5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway

cell differentiation and apoptosis

This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2

Shc(Phospho Tyr427) Polyclonal Antibody, 50ul Cell Culture Flasks subcellular location:Localized at the plasmaThis gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2 SOS complex. p66Shc is not involved in Ras activation.