CPSF5 Rabbit Polyclonal Antibody, 100ul Culture Plate Inserts Studies in yeast identified this

Studies in yeast identified this gene as a therapeutic target for Huntington disease

CUL2 not CUL3

The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing

Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors

Transcripts from HIST1H3A lack polyA tails

CPSF5 Rabbit Polyclonal Antibody, 100ul Culture Plate Inserts Studies in yeast identified thisThe protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex which is composed of four polypeptides.