Mouse Microtubule-associated Protein 1 Light Chain 3 Alpha, MAP1LC3A ELISA Kit , 96T Biochemical Reagents Loss or altered expression of

Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers

II and III

It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor

The tenascins have anti-adhesive effects

This gene is significantly upregulated in Fanconi's anemia fibroblasts but downregulated or absent in fibroblasts from normal donors

Mouse Microtubule-associated Protein 1 Light Chain 3 Alpha, MAP1LC3A ELISA Kit , 96T Biochemical Reagents Loss or altered expression ofUbiquitin like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP GATE 16 subfamily is essential for a later stage in autophagosome maturation.