ALK(Phospho-Tyr1586) Polyclonal Antibody, 100ul Centrifugal Filter Four alternatively spliced transcript variants

Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported

The protein consists of a tetramer of identical subunits

The coiled-coil motif is involved in homodimerization

S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells

although it partially localizes in the nucleus

ALK(Phospho-Tyr1586) Polyclonal Antibody, 100ul Centrifugal Filter Four alternatively spliced transcript variantsThis gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a