Human Mannosyl-oligosaccharide 1, MAN1A1 ELISA Kit, 96T Immunoassays The core clock genes: PER1/2/3

The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression

Mapped to a previously identified cluster of cadherin genes on chromosome 16q22

Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation (PubMed: 28903391)

It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells

This gene is located in a cluster of related genes on chromosome 19 and there is a pseudogene for this gene on chromosome 3

Human Mannosyl-oligosaccharide 1, MAN1A1 ELISA Kit, 96T Immunoassays The core clock genes: PER1/2/3