MSH2 Monoclonal Antibody, 100ul Sampling Tubes Three protein-coding and one non-coding

Three protein-coding and one non-coding transcript variant have been found for this gene

tissue specificity:Expressed predominantly in lung

Also acts as a regulator of cell polarity

Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection

Upon binding the hormone ligand

MSH2 Monoclonal Antibody, 100ul Sampling Tubes Three protein-coding and one non-codingThis locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.