EMR2 Polyclonal Antibody, 20ul[BT-AP02942] Modified Oligos Defects in TMEM237 are a

Defects in TMEM237 are a cause of Joubert syndrome-14

CD30 ligand (CD30L)/TNFSF8 is a type II membrane protein belonging to the TNF superfamily

The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis

it ensures optimal cell growth and viability

also located on chromosome 10

EMR2 Polyclonal Antibody, 20ul[BT-AP02942] Modified Oligos Defects in TMEM237 are aADGRE2 encodes a member of the class B seven span transmembrane (TM7) subfamily of G protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N terminal epidermal growth factor like domains coupled to a TM7 domain via a mucin like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell cell adhesion through interaction with chondroitin sulfate