Presenilin 1(Phospho Ser357) Polyclonal Antibody, 100ul CellSafe™ the full-length nature of some

the full-length nature of some of these variants has not yet been determined

This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium

This kinase blocks the ubiquitination of tumor suppressor p53

15-kD protein

colon and intestine

Presenilin 1(Phospho Ser357) Polyclonal Antibody, 100ul CellSafe™ the full-length nature of someAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma secretase, an enzyme that cleaves APP.