TDH Rabbit Polyclonal Antibody, 100ul Thermo Mix Mutations in this gene are

Mutations in this gene are associated with Ehlers-Danlos syndrome| types I and II

It also functions as a repressor of NF-kappa-B by promoting ubiquitination of the NF-kappa-B subunit RELA in a HAT-independent manner

heart defects

where it constitutes the regulatory subunit

MAPK15 is a ubiquitously expressed protein with highest expression found in lung and kidney

TDH Rabbit Polyclonal Antibody, 100ul Thermo Mix Mutations in this gene areThis gene appears to be an evolving pseudogene of L threonine 3 dehydrogenase (TDH). In both prokaryotes and eukaryotes TDH catalyzes the first of two steps in one of two L threonine degradation pathways. However in human the single gene with sequence similarity to TDH is not capable of encoding a functional TDH protein; the predicted protein lacks most of the C terminus and parts of the NAD+ binding motif when compared to other species' TDH proteins.