HMGN1/2/3/4 Rabbit Polyclonal Antibody, 100ul Cell Proliferation including the BRCA1-A complex and

including the BRCA1-A complex and the BRISC complex

thus| it functions as a regulator of a wide variety of downstream proteins| including tumor suppressor proteins p53 and BRCA1| checkpoint kinase CHK2| checkpoint proteins RAD17 and RAD9| and DNA repair protein NBS1

May play a role in the establisment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity

Mitogen-activated protein kinase kinase kinase MLT

The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired

HMGN1/2/3/4 Rabbit Polyclonal Antibody, 100ul Cell Proliferation including the BRCA1-A complex andThe protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein HMG17 the encoded protein may help maintain an open chromatin configuration around transcribable genes.