Shc(Phospho Tyr349) Polyclonal Antibody, 100ul Pathway and Network Analysis Members of this protein family

Members of this protein family have six EF-hand domains which bind calcium

the encoded protein binds to the ER stress response element

Loss of sequences from human chromosome 10q has been associated with the progression of human cancers

Although the BCR-ABL fusion protein has been extensively studied

78 kDa glucose-regulated protein encoded by HSPA5 is a member of the heat shock protein 70 (HSP70) family

Shc(Phospho Tyr349) Polyclonal Antibody, 100ul Pathway and Network Analysis Members of this protein familyThis gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2 SOS complex. p66Shc is not involved in Ras activation.