Rb (Acetyl-K873/K874) Polyclonal Antibody, 20ul Vortex Mixer Kinases that recognize phosphorylation sites

Kinases that recognize phosphorylation sites in which the surrounding peptides have an alpha-helical conformation

The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding

Mutations in this gene are a cause of spastic ataxia 2| autosomal recessive

It associates with kinesin heavy chain through an N-terminal domain

Several transcript variants encoding different isoforms have been found for this gene

Rb (Acetyl-K873/K874) Polyclonal Antibody, 20ul Vortex Mixer Kinases that recognize phosphorylation sitesThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.