EMAL4 Rabbit Polyclonal Antibody, 100ul Endonucleases & Exonucleases with deletion of the Golgi

with deletion of the Golgi and endoplasmic reticulum signals resulting in abnormal subcellular localization

Containing six NHR (neuralized homology repeat) domains

Mutations at this locus have been associated with microcephaly| seizures| and developmental delay

Mutations in this gene result in Currarino syndrome

Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA| heparin and the cell surface

EMAL4 Rabbit Polyclonal Antibody, 100ul Endonucleases & Exonucleases with deletion of the GolgiThis gene is a member of the echinoderm microtubule associated protein like family. The encoded WD repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene which generates EML4 ALK fusion transcripts is one of the primary mutations associated with non small cell lung cancer. Alternative splicing of this gene results in two transcript variants.