LAT Polyclonal Antibody, 100ul[BT-AP04959] Immuno Plates Two alternatively spliced transcript variants

Two alternatively spliced transcript variants have been described

Expression of this gene is tightly coordinated with expression of the neighboring gene TMEM216

Mediates apoptosis and actin stress fiber dissolution

Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy

Contains 2 MIB/HERC2 domains

LAT Polyclonal Antibody, 100ul[BT-AP04959] Immuno Plates Two alternatively spliced transcript variantsLinker for activation of T cells family member 1 encoded by LAT is phosphorylated by ZAP 70 Syk protein tyrosine kinases following activation of the T cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular