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MDMX Polyclonal Antibody, 50ul Cell Dissociation It associates with Ret to

SKU: 58101054896

4.4
EUR185.00 EUR216.00

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MDMX Polyclonal Antibody, 50ul Cell Dissociation It associates with Ret toMDM4 encodes a nuclear protein that contains a p53 binding domain at the N terminus and a RING finger domain at the C terminus, and shows structural similarity to p53 binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain.

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Description

It associates with Ret to transduce Ret-mediated processes such as axonal projection

CEP55 (Centrosomal protein of 55 kDa)

most of which are necessary for proper CEP55 function

This protein may also play a role autophagy in certain cancer cells by regulating the autophagosome initiation complex

the interaction is direct

MDMX Polyclonal Antibody, 50ul Cell Dissociation It associates with Ret toMDM4 encodes a nuclear protein that contains a p53 binding domain at the N terminus and a RING finger domain at the C terminus, and shows structural similarity to p53 binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain.

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