Apaf-1-ALT Polyclonal Antibody, 20ul Molecular Sciences Defects in this gene that

Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD)

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Apaf-1-ALT Polyclonal Antibody, 20ul Molecular Sciences Defects in this gene thatAPAF1 encodes a cytoplasmic protein that initiates apoptosis. This protein (apoptotic peptidase activating factor 1) contains several copies of the WD 40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent