CENPN Polyclonal Antibody, 50ul Apoptosis & Autophagy The encoded protein is activated

The encoded protein is activated by vascular endothelial growth factor and may regulate angiogenesis

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In addition| the C-terminal kinase domain binds to its own N-terminal region| suggesting potential negative regulation through interference with complex formation via intramolecular binding

|tissue specificity:Expressed in hematopoietic cells and also in colon and testis

NKTR encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain

CENPN Polyclonal Antibody, 50ul Apoptosis & Autophagy The encoded protein is activatedThe protein encoded by this gene forms part of the nucleosome associated complex and is important for kinetochore assembly. It is bound to kinetochores during S phase and G2 and recruits other proteins to the centromere. Pseudogenes of this gene are located on chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms.