Gab 2(Phospho Ser159) Polyclonal Antibody, 20ul Centrifuge Tube (Bottle) The BRCA2-Associated Factor 35 (BRAF35)

The BRCA2-Associated Factor 35 (BRAF35) protein forms a complex with BRCA2

MAP3K7 and TAB1

Interacts with KFL1 (By similarity)

Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain| although some members contain only the sterol-binding domain

This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes

Gab 2(Phospho Ser159) Polyclonal Antibody, 20ul Centrifuge Tube (Bottle) The BRCA2-Associated Factor 35 (BRAF35)This gene is a member of the GRB2 associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T and B cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol 3 kinase in