Neurofibromin Polyclonal Antibody, 50ul Glassware Sets Early growth response 1 encoded

Early growth response 1 encoded by EGR1 belongs to the EGR family of C2H2-type zinc-finger proteins

It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation

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The expression pattern of a similar rat protein suggests that this protein may be involved in neurovascular function in the brain

The expression of this gene is up-regulated by interferon gamma in Th1 cells

Neurofibromin Polyclonal Antibody, 50ul Glassware Sets Early growth response 1 encodedNF1 product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA >Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.