Egr-1 Monoclonal Antibody, 100ul Cell Dissociation and TLE6) are mammalian homologs

and TLE6) are mammalian homologs of Drosophila Groucho

Biochemical and genetic data suggest a role as a tumor suppressor

The encoded protein functions as a transcriptional repressor when heterodimerizing with JUN

This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL)

The potassium voltage-gated channel subfamily H member 3 encoded by KCNH3 is a voltage-gated potassium channel alpha subunit predominantly expressed in the forebrain

Egr-1 Monoclonal Antibody, 100ul Cell Dissociation and TLE6) are mammalian homologsThe protein encoded by this gene belongs to the EGR family of C2H2 type zinc finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene.