SphK2 Polyclonal Antibody, 100ul Cell Screening and Imaging Nuclear pore complexes regulate the

Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm

Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12)

which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains

Human jagged 1 is the ligand for the receptor notch 1

The protein encoded by this gene functions as a receptor for ephrin A2

SphK2 Polyclonal Antibody, 100ul Cell Screening and Imaging Nuclear pore complexes regulate theSPHK2 (sphingosine kinase 2) encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1 phosphate. Sphingosine 1 phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance.