Human Tyrosyl-DNA Phosphodiesterase 1, TDP1 ELISA Kit, 96T Plates & Dishes Interacts with the huntingtin exon

Interacts with the huntingtin exon 1 protein (HDEX1P) containing a glutamine repeat in the pathological range and promotes formation of insoluble polyglutamine-containing aggregates in vivo

ERK and p38 MAPK along with a reduction in reactive oxygen species (ROS)

These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules

It contributes significantly to the pathogenesis of many characteristics of Down syndrome| including morphological features| hypotonia| and mental retardation

PDE4D uses different promoters to generate multiple alternatively spliced transcript variants that encode functiona

Human Tyrosyl-DNA Phosphodiesterase 1, TDP1 ELISA Kit, 96T Plates & Dishes Interacts with the huntingtin exon