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Rb Polyclonal Antibody, 50ul[BT-AP07691] Vector Construction Mutations in this gene have

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Rb Polyclonal Antibody, 50ul[BT-AP07691] Vector Construction Mutations in this gene haveThe protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

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Description

Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK)

axon growth and regeneration

structurally unrelated protein

This gene encodes a protein with six coiled-coil domains

and other neoplasms

Rb Polyclonal Antibody, 50ul[BT-AP07691] Vector Construction Mutations in this gene haveThe protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

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