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Endo180 Polyclonal Antibody, 50ul[BT-AP02955] Molecular Weight Markers The VCX gene cluster is

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Endo180 Polyclonal Antibody, 50ul[BT-AP02955] Molecular Weight Markers The VCX gene cluster isMRC2 encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C type lectin like domains. Mannose receptor C type 2 plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone

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Description

The VCX gene cluster is polymorphic in terms of copy number

Mutations in KRT17 lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex

and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface

The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1

A second transferrin receptor

Endo180 Polyclonal Antibody, 50ul[BT-AP02955] Molecular Weight Markers The VCX gene cluster isMRC2 encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C type lectin like domains. Mannose receptor C type 2 plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone

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