PPR3D Polyclonal Antibody, 50ul Immune Cell Analysis Mutations in NME1 have been

Mutations in NME1 have been identified in aggressive neuroblastomas

They are known to bind several kinases of intermediary metabolism

trimethylamine is primarily converted to the non odorous trimethylamine N-oxide

The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose| but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids

Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed: 17897950

PPR3D Polyclonal Antibody, 50ul Immune Cell Analysis Mutations in NME1 have beenPhosphorylation of serine and threonine residues in proteins is a crucial step in the regulation of many cellular functions ranging from hormonal regulation to cell division and even short term memory. The level of phosphorylation is controlled by the opposing actions of protein kinases and protein phosphatases. Protein phosphatase 1 (PP1) is 1 of 4 major serine threonine specific protein phosphatases which have been identified in eukaryotic cells.