Rb Polyclonal Antibody, 20ul[BT-AP07693] Pathway and Network Analysis In several BTB/POZ containing proteins

In several BTB/POZ containing proteins

AKR1C2 encodes a member of the aldo/keto reductase superfamily

somatic hypermutation and recombination of immunoglobulin genes

As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors

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Rb Polyclonal Antibody, 20ul[BT-AP07693] Pathway and Network Analysis In several BTB/POZ containing proteinsThe protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.