IGF-IR Monoclonal Antibody, 50ul[BT-MCA0100] Cell Culture LIM domains are highly conserved

LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers

and mediate the signal transduction from various receptors of the TNFR superfamily

ALDH3A1 is located within the Smith-Magenis syndrome region on chromosome 17

Because of its pro-apoptotic role

Mutations in this gene cause X-linked Charcot-Marie-Tooth disease

IGF-IR Monoclonal Antibody, 50ul[BT-MCA0100] Cell Culture LIM domains are highly conservedThis receptor binds insulin like growth factor with a high affinity. It has tyrosine kinase activity. The insulin like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have