DKK4 Polyclonal Antibody, 20ul Vector Construction Genetic variation in this gene

Genetic variation in this gene influences susceptibility to occlusive vascular disease

is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils

It also functions as a repressor of NF-kappa-B by promoting ubiquitination of the NF-kappa-B subunit RELA in a HAT-independent manner

Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2)| which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades

in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor

DKK4 Polyclonal Antibody, 20ul Vector Construction Genetic variation in this geneThis gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co receptor and the co factor kremen 2.