PRAM1 Rabbit Polyclonal Antibody, 100ul Cellular Function Assays binding to cyclophilin B and

binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium

A polymorphism in this gene may be associated with rheumatoid arthritis

The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding

Multiple alternatively spliced transcript variants have been identified

The encoded protein product is a preproprotein

PRAM1 Rabbit Polyclonal Antibody, 100ul Cellular Function Assays binding to cyclophilin B andThis gene is a member of the PRAME (preferentially expressed antigen of melanoma) gene family which is expressed in many cancers but may function in reproductive tissues during development. Alternative promoter usage generates two transcript variants which encode different isoforms.