INT7 Rabbit Polyclonal Antibody, 50ul Peripheral Blood Separation Tube Mutations in this gene cause

Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex

by preferential cleavage: -Ala-|-Xaa- > -Val-|-Xaa-

It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways

Belongs to the LDH/MDH superfamily

It is also found to be expressed in lipogenic breast cancers| which suggests a role in controlling tumor lipid metabolism

INT7 Rabbit Polyclonal Antibody, 50ul Peripheral Blood Separation Tube Mutations in this gene causeThis gene encodes a subunit of the integrator complex. The integrator complex associates with the C terminal domain of RNA polymerase II and mediates 3' end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.