Rb(Phospho Ser811) Polyclonal Antibody, 100ul Cell Separation and Collection These proteins are characterized by

These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures

may also function in some cell surface adhesion or recognition processes

BARD1 encodes a protein which interacts with the N-terminal region of BRCA1

This protein may also play a role in maintaining the membrane permeability barrier| and knockdown of this gene in human cells results in the release of cytochrome c and apoptosis

The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA

Rb(Phospho Ser811) Polyclonal Antibody, 100ul Cell Separation and Collection These proteins are characterized byThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.