Rb Polyclonal Antibody, 100ul[BT-AP07691] sgRNA Oligos Alternatively spliced transcript variants for

Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined

It functions as part of the EGFR pathway

This gene encodes a single-pass membrane protein| which contains a conserved sequence of the GCN5 or NAT superfamily of N-acetyltransferases and is a member of the N-acyltransferase (NAT) superfamily

It is induced by heat shock and treatment with the HSP 90 inhibitor 17-demeth-oxygeldanamycin

This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level

Rb Polyclonal Antibody, 100ul[BT-AP07691] sgRNA Oligos Alternatively spliced transcript variants forThe protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.