NPL4 Polyclonal Antibody, 100ul 3D Culture This gene is clustered with

This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19

The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain

tissue specificity:Highly expressed in brain

The protein is implicated in the function of the permability transition pore complex (PTPC)

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome

NPL4 Polyclonal Antibody, 100ul 3D Culture This gene is clustered withBinds ubiquitinated proteins via its RanBP2 type zinc finger.,The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4 UFD1L VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope.,pathway: Protein degradation;