Calregulin Polyclonal Antibody, 100ul Pathway and Network Analysis Mutations in this gene are

Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2

The protein encoded by this gene belongs to the Nudix hydrolase family

This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation

This gene lies in a region of the X chromosome which has been associated with mental retardation

The protein can efficiently bind the NGFI-B Response Element (NBRE)

Calregulin Polyclonal Antibody, 100ul Pathway and Network Analysis Mutations in this gene areCalreticulin is a multifunctional protein that acts as a major Ca (2+) binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain