Cbl Polyclonal Antibody, 50ul[BT-AP01263] Cell fragmentation and collection Aberrant expression of this gene

Aberrant expression of this gene in adult tissues is associated with tumorigenesis

It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p

multiple polyadenylation sites are found in the 3' UTR

Read-through transcription also exists between this gene and the downstream EGFL8 (EGF-like-domain| multiple 8) gene

tissue specificity:Expressed in lung and macrophages

Cbl Polyclonal Antibody, 50ul[BT-AP01263] Cell fragmentation and collection Aberrant expression of this geneCBL is a proto oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein (Cbl proto oncogene) is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine phosphorylated