Topo II alpha(Phospho Thr1343) Polyclonal Antibody, 20ul Cryopreservation and regulation of cell volume

and regulation of cell volume

This protein is overexpressed in epithelial mesotheliomas| ovarian cancers and in specific squamous cell carcinomas

The protein encoded by this gene lacks the protease domain

in a calcium-dependent manner

highly conserved DNA-binding motif

Topo II alpha(Phospho Thr1343) Polyclonal Antibody, 20ul Cryopreservation and regulation of cell volumeThis gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus