SIK2 Polyclonal Antibody, 50ul Protein Research The product of this gene

The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues

and has higher inhibitory activity when phosphorylated

Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis

and localizes to the Golgi apparatus

This gene encodes the interleukin 1 receptor accessory protein

SIK2 Polyclonal Antibody, 50ul Protein Research The product of this geneCatalytic activity: ATP + a protein = ADP + a phosphoprotein.,cofactor: Magnesium.,enzyme regulation: Activated by phosphorylation on Thr 175 by STK11 in complex with STE20 related adapter alpha (STRAD alpha) pseudo kinase and CAB39.,Phosphorylates 'Ser 794' of IRS1 in insulin stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB specific