ITGA6 Rabbit Polyclonal Antibody, 20ul Reservoirs Alternative splicing from the Golli

Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products

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The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport

Found only where the chromosome cores are synapsed

Three transcript variants encoding distinct isoforms have been identified for this gene

ITGA6 Rabbit Polyclonal Antibody, 20ul Reservoirs Alternative splicing from the Gollialternative products: Additional isoforms seem to exist. There is a combination of at least four alternatively spliced domains two extracellular (X1 and X2) and two cytoplasmic (A and B). So far detected are isoform Alpha 6X1A isoform Alpha 6X1B and isoform Alpha 6X1X2A (minor). Experimental confirmation may be lacking for some isoforms disease: Defects in ITGA6 are a cause of epidermolysis bullosa with pyloric atresia (EB PA)