Mdm2 Polyclonal Antibody, 20ul[BT-AP05302] Metabolic enzymes A related mRNA suggests an

A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence

and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex

This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes

where it converts cholesteryl esters to free cholesterol for steroid hormone production

but was not secreted

Mdm2 Polyclonal Antibody, 20ul[BT-AP05302] Metabolic enzymes A related mRNA suggests anMDM2 encodes a nuclear localized E3 ubiquitin ligase. E3 ubiquitin protein ligase Mdm2 can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. MDM2 is itself transcriptionally regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript