Oct-3/4 Monoclonal Antibody, 100ul[BT-MCA0954] Cell Function Analysis Mutations in IGLL1 can result

Mutations in IGLL1 can result in B cell deficiency and agammaglobulinemia

a subunit also shared by the receptor complex for interleukin 10 (IL10)

Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles

The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32

This gene is a candidate gene for autosomal dominant retinitis pigmentosa

Oct-3/4 Monoclonal Antibody, 100ul[BT-MCA0954] Cell Function Analysis Mutations in IGLL1 can resultThis gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non AUG translation initiation