LIMK-1/2 Polyclonal Antibody, 50ul miRNA / siRNA Synthesis SPI1 encodes an ETS-domain transcription

SPI1 encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development

PAX2 encodes paired box gene 2

GATA2 (GATA binding protein 2) encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes

a glycine/phenylalanine (G/F)-rich region

The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface

LIMK-1/2 Polyclonal Antibody, 50ul miRNA / siRNA Synthesis SPI1 encodes an ETS-domain transcriptionThere are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein protein interactions. LIM kinase 1 and LIM kinase 2 belong to a small subfamily with a unique combination of 2 N terminal LIM motifs and a C terminal protein kinase