MDMX Monoclonal Antibody, 100ul Micro Centrifuge Tubes Mutation in DLX5

Mutation in DLX5

The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases

and retinoblastoma-like protein 2 (RBL2

This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway

A polymorphism in an intron of this gene may be associated with longevity

MDMX Monoclonal Antibody, 100ul Micro Centrifuge Tubes Mutation in DLX5This gene encodes a nuclear protein that contains a p53 binding domain at the N terminus and a RING finger domain at the C terminus, and shows structural similarity to p53 binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation