p57(Phospho Thr310) Polyclonal Antibody, 100ul Aspirating Pipets Pseudogenes of this gene are

Pseudogenes of this gene are present on chromosomes 1| 3| 9| 12 and 20| and on the X chromosome

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This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes

In addition| protein levels decrease in the presence of natural killer lytic-associated molecule| suggesting that association with natural killer lytic-associated molecule results in ubiquitination and subsequent degradation of this protein

This gene encodes a preproprotein that is proteolytically processed to generate two protein products| megakaryocyte potentiating factor and mesothelin

p57(Phospho Thr310) Polyclonal Antibody, 100ul Aspirating Pipets Pseudogenes of this gene areThis gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight binding, strong inhibitor of several G1 cyclin Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.