ACATN Polyclonal Antibody, 50ul CellSafe™ The protein encoded by POLR1C

The protein encoded by POLR1C (RNA polymerase I subunit C) is a subunit of both RNA polymerase I and RNA polymerase III complexes

This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily

and thereby promoting the formation of actin filaments

It is highly homologous to the myelin protein zero and| in thymus-derived epithelial cell lines| is poorly soluble in nonionic detergents| strongly suggesting an association to the cytoskeleton

At least three alternatively spliced variants encoding distinct proteins have been reported

ACATN Polyclonal Antibody, 50ul CellSafe™ The protein encoded by POLR1CThe protein encoded by this gene is required for the formation of O acetylated (Ac) gangliosides. The encoded protein is predicted to contain 6 to 10 transmembrane domains and a leucine zipper motif in transmembrane domain III. Defects in this gene have been reported to cause spastic paraplegia autosomal dominant type 42 (SPG42) in one Chinese family but not in similar patients of European descent. Two transcript variants encoding the same protein