PIAS 3 Polyclonal Antibody, 50ul Metabolic enzymes The encoded protein mitochondrial ribosomal

The encoded protein mitochondrial ribosomal protein S18C is one of three that has significant sequence similarity to bacterial S18 proteins

This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined

Among its related pathways are Metal ion SLC transporters

it and another family member

and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway

PIAS 3 Polyclonal Antibody, 50ul Metabolic enzymes The encoded protein mitochondrial ribosomalPIAS3 encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. Protein inhibitor of activated STAT 3 functions as a SUMO (small ubiquitin like modifier) E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity.